Introduction: To study possible causes of cerebral injury during intubation we studied cerebral blood flow velocities (CBFV) in a prospective randomized trial in infants during halothane and propofol anesthesia; as halothane compromises and propofol preserves cerebrovascular autoregulation.
Methods: n = 20 infants (<10 kg) undergoing minor elective surgery were studied. CBFV were assessed in MCA with a transcranial Doppler system (DWL, Multi Dop X; ISPTA: 1,5-5 mW/cm2) allowing continuous measurements, during premedication (midazolam) and halothane (1.5-2.0 Vol%) or propofol anesthesia (i.v.3-5mg/kg). Data were analysed by Wilcoxon-signed-rank-test.
Results: Table
Conclusion: CBFV increased significantly during intubation both under halothane and propofol anesthesia. In high risk infants, with compromised cerebrovascular autoregulation and possible preexisting brain injury, such hemodynamic changes might be harmful. Thus strategies to avoid significant alterations have to be worked out. Supported by the Austrian Research Foundation (FWF-Nr-9342) & DWL Instruments, Germany
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Ipsiroglu, O., Kuhle, S., Köhler, J. et al. EFFECTS OF INTUBATION ON CEREBRAL BLOOD FLOW VELOCITIES IN INFANTS UNDER HALOTHANE AND PROPOFOL ANESTHESIA † 917. Pediatr Res 41 (Suppl 4), 155 (1997). https://doi.org/10.1203/00006450-199704001-00936
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DOI: https://doi.org/10.1203/00006450-199704001-00936
