Background: To examine the postnatal development of AngII vasoconstictory effect and the role of AT1 and AT2 receptors in the in vitro, rabbit isolated perfused kidney (IPK).
Subjects: Rabbit IPK provening form 7 and 42 day (d)-old animals.
Interventions: Kidneys were perfused at constant flow with an oxygenated, modified Krebs-Enselheit medium. Increases in perfusion pressure(IPP) were measured in response to AngII, 10-10M and 10-8M, in the presence of L158809 (L), 0.5 μM, or PD123319 (PD), 0.5 μM, respectively AT1- and AT2-receptors antagonists
Results: (means ± SEM; (*): p<0.05 vs controls): Table
L, 0.5 μM, completely antagonized Angil effects in all the experimental conditions.
Conclusions: Postnatal AngII renal vascular reactivity follows a specific developmental pattern in the rabbit IPK, which involves AT1 and AT2 receptors. A greater magnitude of AT2-mediated AngII effects can be evidenced in the neonatal IPK.
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Simeoni, U., Zhu, B., Geisert, J. et al. Postnatal Development of Angiotensin II (AngII) Renal Vascular Reactivity. Role of ANGII Receptor Subtypes. 225. Pediatr Res 40, 552 (1996). https://doi.org/10.1203/00006450-199609000-00248
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DOI: https://doi.org/10.1203/00006450-199609000-00248
