The purpose of our study was to evaluate the developmental changes in fetal blood bilirubin binding capacity. Patients were divided in two groups: 47 term(BW=3172±393g, GA=39.5±1.1 weeks) and 39 preterm infants(BW=2012±467g; GA=34.1±1.9 weeks). Cord blood was drawn and enriched with six bilirubin concentrations: 5, 10, 15, 20, 25 and 30 mg/dl.
Total bilirubin - B (Jendrassik-Gróf), serum albumin - A (bromcresol green) and free bilirubin - FB (horseradish peroxidase) were measured and the following parameters were compared between term and preterm cord sera: B× FB and bilirubin/albumin molar ratio B/A × FB.
Regression lines were drawn for B × FB and B/A × FB and compared by t-test. Determination coeficients were calculated. Significance was considered when p <.05. Table
No differences were noted between preterm and term cord sera bilirubin binding capacity. The bilirubin binding capacity does not change with gestational age, implying that the greater risk for kernicterus in the preterm infants is mostly related to their lower albumin concentration. (Funded by Trilab Diagnóstica Ltd.)
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(Spon. by Jaques Belik).
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Barros, M., Viecili, M., Almeida, M. et al. CORRELATION BETWEEN BILIRUBIN, BILIRUBIN ALBUMIN MOLAR RATIO AND FREE BILIRUBIN IN PRETERM AND TERM CORD BLOOD SERA. 1149. Pediatr Res 39 (Suppl 4), 194 (1996). https://doi.org/10.1203/00006450-199604001-01171
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DOI: https://doi.org/10.1203/00006450-199604001-01171
