Abstract
The very latest amniotic fluid (AF) samples obtained from mothers whose pregnancies were complicated by PROM (67 samples) and gastric aspirates (GA) samples obtained from premature infants admitted to NICU for possible treatment of RDS (166 samples) when indicated were analyzed for surface active phospholipids using two zone, thin-layer liquid chromotography following separation of disaturated to obtain LPPS. Results were obtained during the period 9/79 to 6/84 and compared with clinical and xray evidence of RDS among 233 premature infants studied. The following results indicate the risk of RDS vs LPP results to date
Within these results, it should be noted that transitional LPPs from AF samples indicated only a 57.1% risk (8/14) while LPPs from GA indicated an 88% risk (22/25)(p< .05 by 2-way ANOVA) suggesting that the closer the profile is performed to birth, the more accurate. Both AF & GA LPPs showed a linear correlation with maturation and gestational age. The more mature the profile the greater the GA with the exception of 6 infants with mature(c) LPPs who developed RDS. Of the 6, none were class A IDMs.
Conclusion: Infants who demonstrate LPPs which are transitional or less mature have a > 85% risk of developing RDS. LPP provides a valuable tool in guiding obstetric and neonatal care of infants at risk for respiratory distress syndrome.
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Bonta, B., Gill, W. & Stanley Porter, F. 1345 RISK OF RESPIRATORY DISTRESS SYNDROME (RDS) FROM VERY LATEST SAMPLING FOR LUNG PHOSPHOLIPID PROFILE (LPP) BEFORE OR AT BIRTH AMONG INFANTS WITH MATERNAL PROM. Pediatr Res 19, 335 (1985). https://doi.org/10.1203/00006450-198504000-01369
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DOI: https://doi.org/10.1203/00006450-198504000-01369
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