Abstract
The pathogenesis of MCNS remains unknown.It has been postulated that this disease could be the result of a sistemic T cell dysfunction.In this study,we report certain parameters of cell mediated immunity on 25 well nourished children aged 1-14 yrs.with MCNS.Thirteen of them,were studied during active nephrosis and 12 during complete remission.Percentage and absolute number of E-Rosettes,skin reactivity to PPD,SK-SD, DNCB and lymphocyte proli-ferative response were determined. Number of T lymphocytes was normal in all nephrotic children. Active patients were unable of becoming sensitized to DNCB but PPD and SK-SD skin reactivity was similar to controls.Phytohemaglutinin (PHA) proliferative response was expressed as stimulation index i.e. cpm mitogen stimulated cultures/cpm unstimulated cultures (SI). In active nephrosis SI was 10.5,during remission 55.6 and 69.6 in controls. There was statistical significance between active and controls and between active and remission infants.SI of active nephrotic children return to normal values when their lymphocytes were incubated with normal homologous plasma.SI decreased when normal lymphocytes were incubated with nephrotic plasma.We suggest that in MCNS there is a T cell subpopulation disbalance with an overactive T supressor clone.
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Fodor, P., Saitúa, M., Rodríguez, E. et al. 20 T CELL DISFUNCTION IN MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) OF CHILDHOOD. Pediatr Res 15, 179 (1981). https://doi.org/10.1203/00006450-198102000-00040
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DOI: https://doi.org/10.1203/00006450-198102000-00040