Abstract
Three courses of metotrexate, 500 mg/sq.m. at 3 - weekly intervals, has been used as part of a consolidation therapy in Norway during the last four years to 110 children with acute lymphocytic leukemia. One child died following HDM. Postmortem examination showed that she was not in complete remission at the time.
Sixty-eight of eighty-one children (84%) in lst remission have been in substained primary remission for 4 to 54 months. Five of the children died from infections 1-2 years after induction therapy. Therapy has been discontinued in 19 patients so far, none of them have relapsed.
There has been two cases of CNS-leukemia among the 81 cases in 1st remission, and no recorded case of testicular involvement so far.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moe, P. 21 HIGH DOSE METOTREXATE IN ACUTE LYMPHOCYTIC LEUKEMIA IN CHILDHOOD. Pediatr Res 13, 951 (1979). https://doi.org/10.1203/00006450-197908000-00037
Issue Date:
DOI: https://doi.org/10.1203/00006450-197908000-00037