Abstract
Poly(L-glutamic acid) microspheres (PLGM) were obtained from hydrolysis of poly(γ-benzyl-L-glutamate) microspheres prepared by the precipitation polymerization in polystyrene solution. The degradation behavior of PLGM was investigated, and were led to the polymer prodrugs such as PLGM-5-FU and PLGM-Glc-5-FU conjugated 1,2-dihydroxy methyl-5-fluorouracil (DHM-5-FU), or D-glucosamine-5-fluorouracil (Glc-5-FU) on PLGM. The release behaviors of 5-FU derivatives from the prodrugs were investigated in vitro, and antitumor activities were tested against Sarcoma-180 ascites in vivo. Drug release rate from PLGM-Glc-FU was relatively rapid and higher antitumor activity than from PLGM-5-FU.
Similar content being viewed by others
Article PDF
References
M. Shahar, H. Meshulam, and S. Margel, J. Polym. Sci., Polym. Chem. Ed., 24, 203 (1986).
C. M. Klech and X. Li, J. Pharm. Sci., 79, 999 (1990).
T. Hayashi, E. Nakanishi, Y. Iizukn, M. Oya, and M. Iwatsuki, Eur. Polym. J., 30, 1065 (1994).
H. Ihara, T. Yoshinaga, Y. Motozato, and C. Hirayama, Polym. J., 17, 1301 (1985).
K. S. Kim and N. B. Graham, Polym. J., 31, 809 (1999).
S. Ozaki, I. Ike, H. Mizuno, K. Ishikawa, and H. Mori, Bull. Chem. Soc. (Japan), 50, 2406 (1975).
P. P. Umrigar, S. Ohashi, and G. B. Butler, J. Polym. Sci., Polym. Ed., 17, 351 (1979).
T. Ouchi, H. Yuyama, and O. Vogl, Makromol. Chem., Rapid Commun., 6, 815 (1985).
S. Poul and B. Rang, J. Appl. Polym. Sci., 26, 3927 (1981).
G. Levin and H. N. Nae, J. Appl. Polym. Chem. Ed., 23, 981 (1985).
H. Endoh, T. Kawaguchi, T. Seki, T. Hasegawa, and K. Jumi, Chem. Pharm. Bull., 39, 458 (1991).
T. Kawaguchi, Y. Suzuki, Y. Nakahara, N. Nambu, and T. Nagai, Chem. Pharm. Bull., 33, 301 (1985).
S. Ozaki, T. Nagase, H. Tamai, H. Mori, A. Hoshi, and M. Ligo, Chem. Pharm. Bull., 35, 3894 (1987).
T. Ouchi, H. Kobayashi, and T. Banba, Br. Polym. J., 23, 221 (1990).
M. Tada, Bull. Chem. Soc. Jpn., 48, 3429 (1975).
K. S. Kim, S. H. Cho, and J. K. Kang, Polymer (Korea), 18, 877 (1995).
G. Holzwarth and P. Doty, J. Am . Chem. Sci., 81, 218 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kim, K., Kim, T. & Graham, N. Controlled Release Behavior of Prodrugs Based on the Biodegradable Poly(L-glutamic acid) Microspheres. Polym J 31, 813–816 (1999). https://doi.org/10.1295/polymj.31.813
Issue Date:
DOI: https://doi.org/10.1295/polymj.31.813
Keywords
This article is cited by
-
Aggregates formation and pH response of mixed dodecyl-terminated copolypeptides containing tryptophan
Colloid and Polymer Science (2008)