Abstract
A novel type of methacrylate bearing a phosphorylcholine analogous group, 2-[3ā²-(trimethylammonium)propylphosphoryl]ethyl methacrylate (TPM) was synthesized. TPM was polymerized and copolymerized with vinyl monomers in the presence of radical initiators. Monomer reactivity ratios and Q and e for TPM were determined. A critical micelle concentration (CMC) of TPM was 3.6Ć10ā3 mol lā1. Two types of copolymer microspheres of methyl methacrylate (MMA) with TPM or 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared from emulsifier-free emulsion copolymerizations over the CMC. The suppression of bovine serum albumin (BSA) adsorption onto poly(TPM-co-MMA) microsphere was similar to that onto the poly(MPC-co-MMA). The length of three methylene units between zwitter-ions in the phosphorylcholine group could not prevent depressing BSA adsorption.
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Oishi, T., Uchiyama, H., Onimura, K. et al. Synthesis and Properties of Poly(methacrylate) Bearing a Phosphorylcholine Analogous Group. Polym J 30, 17ā22 (1998). https://doi.org/10.1295/polymj.30.17
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DOI: https://doi.org/10.1295/polymj.30.17
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