Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Clinical Research

Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy?

Prostate Cancer and Prostatic Diseases volume 14, pages 74–78 (2011)Cite this article

Subjects

Abstract

The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients. We examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high-grade tumor was defined as having a Gleason score ⩾8. Univariable and multivariable logistic regression analyses were used to test the relationship between type 2 DM and high-grade tumor. Mean patient age was 64 years (range: 45–85). Mean total PSA level was 9 ng ml−1 (range: 1–89.5). A significantly higher percentage of diabetic patients had high-grade tumor on biopsy (16.3 vs 7.6%; P=0.001) and on RP specimen (21.1 vs 11.7%; P=0.001) in comparison with non-diabetic patients. In multivariable analyses, DM was an independent predictor of high-grade tumor on biopsy (odds ratio=2.31, P=0.001) and on final pathological specimen (odds ratio=2.22, P=0.002). In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Federation ID . Third edition of Diabetes Atlas. 2008. Available from http://www.eatlas.idf.org (accessed 29 March 2010).

  2. Jemal A, Siegel R, Xu J, Ward E . Cancer Statistics 2010. CA Cancer J Clin 2010; 60: 277–300.

    Article  PubMed  Google Scholar 

  3. Bonovas S, Filioussi K, Tsantes A . Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia 2004; 47: 1071–1078.

    Article  CAS  PubMed  Google Scholar 

  4. Kasper JS, Giovannucci E . A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006; 15: 2056–2062.

    Article  PubMed  Google Scholar 

  5. Baradaran N, Ahmadi H, Salem S, Lotfi M, Jahani Y, Baradaran N et al. The protective effect of diabetes mellitus against prostate cancer: role of sex hormones. Prostate 2009; 69: 1744–1750.

    Article  CAS  PubMed  Google Scholar 

  6. Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev 2006; 15: 1977–1983.

    Article  PubMed  Google Scholar 

  7. Leitzmann MF, Ahn J, Albanes D, Hsing AW, Schatzkin A, Chang SC et al. Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Causes Control 2008; 19: 1267–1276.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jayachandran J, Aronson WJ, Terris MK, Presti Jr JC, Amling CL, Kane CJ et al. Diabetes and outcomes after radical prostatectomy: are results affected by obesity and race? Results from the shared equal-access regional cancer hospital database. Cancer Epidemiol Biomarkers Prev 2010; 19: 9–17.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chan JM, Latini DM, Cowan J, Duchane J, Carroll PR . History of diabetes, clinical features of prostate cancer, and prostate cancer recurrence-data from CaPSURE (United States). Cancer Causes Control 2005; 16: 789–797.

    Article  CAS  PubMed  Google Scholar 

  10. Davis JW, Kim J, Ward JF, Wang X, Nakanishi H, Babaian RJ et al. Radical prostatectomy findings in patients predicted to have low-volume/low-grade prostate cancer diagnosed by extended-core biopsies: an analysis of volume and zonal distribution of tumor foci. BJU Int 2009; 105: 1386–1391.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kvale R, Moller B, Wahlqvist R, Fossa SD, Berner A, Busch C et al. Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: a population-based study. BJU Int 2009; 103: 1647–1654.

    Article  PubMed  Google Scholar 

  12. Moussa AS, Kattan MW, Berglund R, Yu C, Fareed K, Jones JS . A nomogram for predicting upgrading in patients with low- and intermediate-grade prostate cancer in the era of extended prostate sampling. BJU Int 2010; 105: 352–358.

    Article  PubMed  Google Scholar 

  13. Moussa AS, Li J, Soriano M, Klein EA, Dong F, Jones JS . Prostate biopsy clinical and pathological variables that predict significant grading changes in patients with intermediate and high grade prostate cancer. BJU Int 2009; 103: 43–48.

    Article  PubMed  Google Scholar 

  14. Calton BA, Chang SC, Wright ME, Kipnis V, Lawson K, Thompson FE et al. History of diabetes mellitus and subsequent prostate cancer risk in the NIH-AARP Diet and Health Study. Cancer Causes Control 2007; 18: 493–503.

    Article  PubMed  Google Scholar 

  15. Kasper JS, Liu Y, Giovannucci E . Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study. Int J Cancer 2009; 124: 1398–1403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Coker AL, Sanderson M, Zheng W, Fadden MK . Diabetes mellitus and prostate cancer risk among older men: population-based case-control study. Br J Cancer 2004; 90: 2171–2175.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, San Raffaele Hospital, Vita-Salute University, Milan, Italy

    F Abdollah, A Briganti, N Suardi, A Gallina, U Capitanio, A Salonia, A Cestari, G Guazzoni, P Rigatti & F Montorsi

Authors
  1. F Abdollah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Briganti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N Suardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Gallina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. U Capitanio
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Salonia
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Cestari
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Guazzoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P Rigatti
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. F Montorsi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F Abdollah.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abdollah, F., Briganti, A., Suardi, N. et al. Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy?. Prostate Cancer Prostatic Dis 14, 74–78 (2011). https://doi.org/10.1038/pcan.2010.41

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/pcan.2010.41

Keywords

This article is cited by

Search

Advanced search

Quick links