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Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy

Oncogene volume 30, pages 1379–1389 (2011)Cite this article

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Abstract

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.

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Acknowledgements

Work in KTJ's laboratory is supported in part by NIAID intramural funds, and work in MM's laboratory is supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan. We thank Lauren Lee for preparation of manuscript and figures, and Junichiro Yasunaga and Linda Zane for discussions.

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  1. Institute for Virus Research, Kyoto University, Kyoto, Japan

    M Matsuoka

  2. Molecular Virology Section, Laboratory of Molecular Microbiology, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    K-T Jeang

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Matsuoka, M., Jeang, KT. Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy. Oncogene 30, 1379–1389 (2011). https://doi.org/10.1038/onc.2010.537

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