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The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

Oncogene volume 29, pages 4865–4873 (2010)Cite this article

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Abstract

The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptional activation. Given its role as a regulator of cellular homeostasis it is not surprising that members of the UPS are frequently aberrantly expressed in a number of disease states including cancer. This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) and mechanisms by which Fbw7 interacts with its substrates in the context of development and tumorigenesis will be discussed. In addition, antagonists of this pathway as well as current and future therapeutics for the UPS will be examined.

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Acknowledgements

We thank the members of the Aifantis Lab for advice and illuminating discussions. Supported by the National Institutes of Health (RO1CA133379, RO1CA105129, R21CA141399, RO1CA149655 and P30CA016087), the American Cancer Society (RSG0806801), the Edward Mallinckrodt Jr Foundation, the Irma T Hirschl Trust, the Alex's Lemonade Stand Foundation (all to IA), NYU Molecular Oncology and Immunology/Ruth L Kirchstein Institutional Training Grant (5T32CA009161 to KC), NYU Cell and Molecular Biology/Ruth L Kirchstein Institutional Traning Grant (BK). IA is a Leukemia & Lymphoma Society Scholar and an Early Career Scientist at the Howard Hughes Medical Institute.

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  1. Department of Pathology, Howard Hughes Medical Institute, NYU School of Medicine, New York, NY, USA

    K M Crusio, B King, L B Reavie & I Aifantis

  2. NYU Cancer Institute and Helen & Martin S Kimmel Stem Cell Center, NYU School of Medicine, New York, NY, USA

    K M Crusio, B King, L B Reavie & I Aifantis

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Crusio, K., King, B., Reavie, L. et al. The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation. Oncogene 29, 4865–4873 (2010). https://doi.org/10.1038/onc.2010.222

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