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Translational symphony in (hnRNP) C major for APP

Nature Structural & Molecular Biology volume 17, pages 675–676 (2010)Cite this article

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Stringent post-transcriptional regulation of the amyloid precursor protein (APP) is critical for maintaining proper neurological function. In this issue, Lee et al. identify two RNA-binding proteins, FMRP and hnRNP C, that have opposite effects on APP translation via competing interactions, surprisingly, with the mRNA coding region.

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Figure 1: Five models for how hnRNP C (blue ball labeled C) may activate translation by binding to an element located in the coding region of an mRNA.

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Authors and Affiliations

  1. Jerome E. Lee and Jeffrey Wilusz are in the Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, Colorado, USA.,

    Jerome E Lee & Jeffrey Wilusz

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  1. Jerome E Lee
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  2. Jeffrey Wilusz
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Correspondence to Jerome E Lee.

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Lee, J., Wilusz, J. Translational symphony in (hnRNP) C major for APP. Nat Struct Mol Biol 17, 675–676 (2010). https://doi.org/10.1038/nsmb0610-675

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