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The end justifies the means

Nature Structural & Molecular Biology volume 12, pages 474–475 (2005)Cite this article

Translation termination, once thought to be the least complex of the steps in protein synthesis, is emerging as a process subject to considerable regulation. The prevalent mode for this regulation seems to be eRF-tweaking, the modulation of release factor activity by proteins involved in other gene expression pathways.

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Figure 1: Mediation of translation termination by the release factors eRF1 and eRF3.
Figure 2: Closed-loop structure of the mRNP.

References

  1. Le Roy, F., Salehzada, T., Bisbal, C., Dougherty, J.P. & Peltz, S.W. Nat. Struct. Mol. Biol. 12, 505–512 (2005).

    Article  CAS  Google Scholar 

  2. Kisselev, L., Ehrenberg, M. & Frolova, L. EMBO J. 22, 175–182 (2003).

    Article  CAS  Google Scholar 

  3. Nakamura, Y., Ito, K. & Ehrenberg, M. Cell 101, 349–352 (2000).

    Article  CAS  Google Scholar 

  4. Nakamura, Y. & Ito, K. Trends Biochem. Sci. 28, 99–105 (2003).

    Article  CAS  Google Scholar 

  5. Frolova, L. et al. Nature 372, 701–703 (1994).

    Article  CAS  Google Scholar 

  6. Stansfield, I. et al. EMBO J. 14, 4365–4373 (1995).

    Article  CAS  Google Scholar 

  7. Zhouravleva, G. et al. EMBO J. 14, 4065–4072 (1995).

    Article  CAS  Google Scholar 

  8. Frolova, L.Y., Merkulova, T.I. & Kisselev, L.L. RNA 6, 381–390 (2000).

    Article  CAS  Google Scholar 

  9. Song, H. et al. Cell 100, 311–321 (2000).

    Article  CAS  Google Scholar 

  10. Inagaki, Y. & Doolittle, W.F. Mol. Biol. Evol. 17, 882–889 (2000).

    Article  CAS  Google Scholar 

  11. Kong, C. et al. Mol. Cell 14, 233–245 (2004).

    Article  CAS  Google Scholar 

  12. Frolova, L. et al. RNA 2, 334–341 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Salas-Marco, J. & Bedwell, D.M. Mol. Cell. Biol. 24, 7769–7778 (2004).

    Article  CAS  Google Scholar 

  14. Czaplinski, K. et al. Genes Dev. 12, 1665–1677 (1998).

    Article  CAS  Google Scholar 

  15. Hoshino, S., Imai, M., Kobayashi, T., Uchida, N. & Katada, T. J. Biol. Chem. 274, 16677–16680 (1999).

    Article  CAS  Google Scholar 

  16. Cosson, B. et al. Mol. Cell. Biol. 22, 3301–3315 (2002).

    Article  CAS  Google Scholar 

  17. Cosson, B. et al. Biol. Cell 94, 205–216 (2002).

    Article  CAS  Google Scholar 

  18. Hosoda, N. et al. J. Biol. Chem. 278, 38287–38291 (2003).

    Article  CAS  Google Scholar 

  19. Mangus, D.A., Evans, M.C. & Jacobson, A. Genome Biol. 4, 223.1–223.14 (2003).

    Google Scholar 

  20. Uchida, N., Hoshino, S., Imataka, H., Sonenberg, N. & Katada, T. J. Biol. Chem. 277, 50286–50292 (2002).

    Article  CAS  Google Scholar 

  21. Tarun, S.Z. Jr. & Sachs, A.B. EMBO J. 15, 7168–7177 (1996).

    Article  CAS  Google Scholar 

  22. Janzen, D.M., Frolova, L. & Geballe, A.P. Mol. Cell. Biol. 22, 8562–8570 (2002).

    Article  CAS  Google Scholar 

  23. Orlova, M., Yueh, A., Leung, J. & Goff, S.P. Cell 115, 319–331 (2003).

    Article  CAS  Google Scholar 

  24. Samuel, C.E. Clin. Microbiol. Rev. 14, 778–809 (2001).

    Article  CAS  Google Scholar 

  25. Karamysheva, Z.N. et al. Nucleic Acids Res. 31, 5949–5956 (2003).

    Article  CAS  Google Scholar 

  26. Matsufuji, S. et al. Cell 80, 51–60 (1995).

    Article  CAS  Google Scholar 

  27. Amrani, N. et al. Nature 432, 112–118 (2004).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Grant support from the US National Institutes of Health (GM27757 and HD48137) is gratefully acknowledged as are the helpful comments of N. Amrani, S. Ghosh, F. He, S. Kervestin, D. Mangus and T. Morrison.

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  1. the Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, 01655-0122, Massachusetts, USA

    Allan Jacobson

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Jacobson, A. The end justifies the means. Nat Struct Mol Biol 12, 474–475 (2005). https://doi.org/10.1038/nsmb0605-474

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