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STAR-studded circuitry

A recent study reports the RNA sequences that bind to the translational repressor protein GLD-1. The data suggest that a network of developmental genes may be regulated by GLD-1 or related STAR proteins through silencing or alternative splicing.

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Figure 1: STAR domain proteins can post-transcriptionally regulate gene expression through translational repression or alternative splicing.

References

  1. Ryder, S.P., Frater, L., Abramovitz, D.L., Goodwin, E.L. & Williamson, J.R. Nat. Struct. Mol. Biol. 11, 20–28 (2004).

    Article  CAS  Google Scholar 

  2. Jan, E., Motzny, C.K., Graves, L.E. & Goodwin, E.B. EMBO J. 18, 258–269 (1999).

    Article  CAS  Google Scholar 

  3. Liu, Z. et al. Science 294, 1098–1102 (2001).

    Article  CAS  Google Scholar 

  4. Saccomanno, L. et al. Proc. Natl. Acad. Sci. USA 96, 12605–12610 (1999).

    Article  CAS  Google Scholar 

  5. Nabel-Rosen, H., Dorevitch, N., Reuveny, A. & Volk, T. Mol. Cell 4, 573–584 (1999).

    Article  CAS  Google Scholar 

  6. Matter, N., Herrlich, P. & Konig, H. Nature 420, 691–695 (2002).

    Article  CAS  Google Scholar 

  7. Berglund, J.A., Chua, K., Abovich, N., Reed, R. & Rosbash, M. Cell 89, 781–787 (1997).

    Article  CAS  Google Scholar 

  8. Zorn, A.M. & Krieg, P.A. Genes Dev. 11, 2176–2190 (1997).

    Article  CAS  Google Scholar 

  9. Lee, M.H. & Schedl, T. Genes Dev. 15, 2408–2420 (2001).

    Article  CAS  Google Scholar 

  10. Marin, V.A. & Evans, T.C. Development 130, 2623–2632 (2003).

    Article  CAS  Google Scholar 

  11. Peled-Zehavi, H., Berglund, J.A., Rosbash, M. & Frankel, A.D. Mol. Cell. Biol. 21, 5232–5241 (2001).

    Article  CAS  Google Scholar 

  12. Bashaw, G.J. & Baker, B.S. Cell 89, 789–798 (1997).

    Article  CAS  Google Scholar 

  13. Grskovic, M., Hentze, M.W. & Gebauer, F. EMBO J. 22, 5571–5581 (2003).

    Article  CAS  Google Scholar 

  14. Penalva, L.O. & Sanchez, L. Microbiol. Mol. Biol. Rev. 67, 343–359 (2003).

    Article  CAS  Google Scholar 

  15. Eisenstein, R.S. Annu. Rev. Nutr. 20, 627–662 (2000).

    Article  CAS  Google Scholar 

  16. Mendez, R. & Richter, J.D. Nat. Rev. Mol. Cell Biol. 2, 521–529 (2001).

    Article  CAS  Google Scholar 

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Butcher, S., Wickens, M. STAR-studded circuitry. Nat Struct Mol Biol 11, 2–3 (2004). https://doi.org/10.1038/nsmb0104-2

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