Two structural studies provide new insights into the mechanisms regulating the DNA binding and activation of human HSF family members.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts
Eye Open Access 03 August 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Balch, W.E., Morimoto, R.I., Dillin, A. & Kelly, J.W. Science 319, 916–919 (2008).
Morimoto, R.I. Cold Spring Harb. Symp. Quant. Biol. 76, 91–99 (2011).
Wolff, S., Weissman, J.S. & Dillin, A. Cell 157, 52–64 (2014).
Hipp, M.S., Park, S.H. & Hartl, F.U. Trends Cell Biol. 24, 506–514 (2014).
Akerfelt, M., Morimoto, R.I. & Sistonen, L. Nat. Rev. Mol. Cell Biol. 11, 545–555 (2010).
Miozzo, F., Sabéran-Djoneidi, D. & Mezger, V. J. Mol. Biol. 427, 3793–3816 (2015).
Nakai, A. Heat Shock Factor (Springer Japan, 2016).
Mendillo, M.L. et al. Cell 150, 549–562 (2012).
Vihervaara, A. et al. Proc. Natl. Acad. Sci. USA 110, E3388–E3397 (2013).
Takii, R. et al. Mol. Cell. Biol. 35, 11–25 (2015).
Neudegger, T., Verghese, J., Hayer-Hartl, M., Hartl, F.U. & Bracher, A. Nat. Struct. Mol. Biol. 23, 140–146 (2016).
Jaeger, A.M., Pemble, C.W. IV, Sistonen, L. & Thiele, D.J. Nat. Struct. Mol. Biol. 23, 147–154 (2016).
Littlefield, O. & Nelson, H.C. Nat. Struct. Biol. 6, 464–470 (1999).
Inouye, S. et al. Mol. Cell. Biol. 23, 5882–5895 (2003).
Westerheide, S.D., Anckar, J., Stevens, S.M. Jr., Sistonen, L. & Morimoto, R.I. Science 323, 1063–1066 (2009).
Raychaudhuri, S. et al. Cell 156, 975–985 (2014).
Ghosh, S.K., Missra, A. & Gilmour, D.S. Mol. Cell. Biol. 31, 4232–4243 (2011).
Yao, J., Munson, K.M., Webb, W.W. & Lis, J.T. Nature 442, 1050–1053 (2006).
Gajiwala, K.S. & Burley, S.K. Curr. Opin. Struct. Biol. 10, 110–116 (2000).
Fujimoto, M. et al. Mol. Cell 48, 182–194 (2012).
Anckar, J. et al. Mol. Cell. Biol. 26, 955–964 (2006).
Tateishi, Y. et al. J. Biol. Chem. 284, 2435–2447 (2009).
Kroeger, P.E. & Morimoto, R.I. Mol. Cell. Biol. 14, 7592–7603 (1994).
Tan, K. et al. Nat. Commun. 6, 6580 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Nakai, A. Molecular basis of HSF regulation. Nat Struct Mol Biol 23, 93–95 (2016). https://doi.org/10.1038/nsmb.3165
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.3165
This article is cited by
-
Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts
Eye (2022)
-
The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response
Archives of Toxicology (2021)
-
Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans
Biogerontology (2020)
-
A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family
Eye (2018)