ATP is continuously synthesized inside mitochondria and exported to the cytoplasm via transporter and channel proteins residing in the inner and outer mitochondrial membranes, respectively. In this issue of Nature Structural & Molecular Biology, a new crystal structure of the mitochondrial channel protein VDAC-1 provides the basis for a detailed simulation study that unravels the mechanism by which ATP diffuses across the outer mitochondrial membrane at a fast rate.
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Faraldo-Gómez, J. Channeling your inner energy. Nat Struct Mol Biol 21, 575–577 (2014). https://doi.org/10.1038/nsmb.2854
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DOI: https://doi.org/10.1038/nsmb.2854