Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Channeling your inner energy

ATP is continuously synthesized inside mitochondria and exported to the cytoplasm via transporter and channel proteins residing in the inner and outer mitochondrial membranes, respectively. In this issue of Nature Structural & Molecular Biology, a new crystal structure of the mitochondrial channel protein VDAC-1 provides the basis for a detailed simulation study that unravels the mechanism by which ATP diffuses across the outer mitochondrial membrane at a fast rate.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rostovtseva, T. & Colombini, M. J. Biol. Chem. 271, 28006–28008 (1996).

    Article  CAS  Google Scholar 

  2. Rostovtseva, T. & Colombini, M. Biophys. J. 72, 1954–1962 (1997).

    Article  CAS  Google Scholar 

  3. Xu, X., Decker, W., Sampson, M.J., Craigen, W.J. & Colombini, M. J. Membr. Biol. 170, 89–102 (1999).

    Article  CAS  Google Scholar 

  4. Rostovtseva, T.K., Tan, W. & Colombini, M. J. Bioenerg. Biomembr. 37, 129–142 (2005).

    Article  CAS  Google Scholar 

  5. Shoshan-Barmatz, V. & Golan, M. Curr. Med. Chem. 19, 714–735 (2012).

    Article  CAS  Google Scholar 

  6. Colombini, M. J. Membr. Biol. 111, 103–111 (1989).

    Article  CAS  Google Scholar 

  7. Rostovtseva, T.K. & Bezrukov, S.M. J. Bioenerg. Biomembr. 40, 163–170 (2008).

    Article  CAS  Google Scholar 

  8. Summers, W.A. & Court, D.A. Biochem. Cell Biol. 88, 425–438 (2010).

    Article  CAS  Google Scholar 

  9. Hiller, S. et al. Science 321, 1206–1210 (2008).

    Article  CAS  Google Scholar 

  10. Ujwal, R. et al. Proc. Natl. Acad. Sci. USA 105, 17742–17747 (2008).

    Article  CAS  Google Scholar 

  11. Bayrhuber, M. et al. Proc. Natl. Acad. Sci. USA 105, 15370–15375 (2008).

    Article  CAS  Google Scholar 

  12. Hiller, S., Abramson, J., Mannella, C., Wagner, G. & Zeth, K. Trends Biochem. Sci. 35, 514–521 (2010).

    Article  CAS  Google Scholar 

  13. Colombini, M. Trends Biochem. Sci. 34, 382–389 (2009).

    Article  CAS  Google Scholar 

  14. Colombini, M. Biochim. Biophys. Acta 1818, 1457–1465 (2012).

    Article  CAS  Google Scholar 

  15. Choudhary, O. et al. Nat Struct. Mol. Biol. 21, 626–632 (2014).

    Article  CAS  Google Scholar 

  16. Corbi-Verge, C. et al. Proc. Natl. Acad. Sci. USA 110, E3372–E3380 (2013).

    Article  CAS  Google Scholar 

  17. Marinelli, F. et al. Proc. Natl. Acad. Sci. USA 108, E1285–E1292 (2011).

    Article  CAS  Google Scholar 

  18. Rui, H., Lee, K.I., Pastor, R.W. & Im, W. Biophys. J. 100, 602–610 (2011).

    Article  CAS  Google Scholar 

  19. Choudhary, O.P. et al. J. Mol. Biol. 396, 580–592 (2010).

    Article  CAS  Google Scholar 

  20. Lee, K.I., Rui, H., Pastor, R.W. & Im, W. Biophys. J. 100, 611–619 (2011).

    Article  CAS  Google Scholar 

  21. Zachariae, U. et al. Structure 20, 1540–1549 (2012).

    Article  CAS  Google Scholar 

  22. Noskov, S.Y., Rostovtseva, T.K. & Bezrukov, S.M. Biochemistry 52, 9246–9256 (2013).

    Article  CAS  Google Scholar 

  23. Song, J., Midson, C., Blachly-Dyson, E., Forte, M. & Colombini, M. J. Biol. Chem. 273, 24406–24413 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to José D Faraldo-Gómez.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Faraldo-Gómez, J. Channeling your inner energy. Nat Struct Mol Biol 21, 575–577 (2014). https://doi.org/10.1038/nsmb.2854

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2854

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing