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PAN-orama: three convergent views of a eukaryotic deadenylase

Nature Structural & Molecular Biology volume 21, pages 577–578 (2014)Cite this article

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Post-transcriptional mRNA regulation is often attained by lengthening or shortening the 3′ poly(A) tail of a transcript. Eukaryotic mRNAs show a spectrum of deadenylation rates, thus allowing intricate control of gene expression, but the mechanisms that determine such rates are unclear. Three new studies highlight the structural and biochemical features of a key enzyme in removing poly(A) tails, the PAN2–PAN3 complex, providing clues to how different mRNA deadenylation rates can be achieved.

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Figure 1: Poly(A)-tail length controls mRNA fate.
Figure 2: A model for how PAN2–PAN3 catalyzes deadenylation.

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Acknowledgements

We thank N. Al Husaini and members of the Coller laboratory for helpful comments. We also thank L. Passmore for a preliminary version of Figure 2. This work was supported by US National Institutes of Health grant GM080465 to J.C.

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  1. Sophie Martin and Jeff Coller are at the Center for RNA Molecular Biology, Case Western Reserve University, Cleveland. Ohio, USA.,

    Sophie Martin & Jeff Coller

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  1. Sophie Martin
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  2. Jeff Coller
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Correspondence to Jeff Coller.

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Martin, S., Coller, J. PAN-orama: three convergent views of a eukaryotic deadenylase. Nat Struct Mol Biol 21, 577–578 (2014). https://doi.org/10.1038/nsmb.2850

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