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Two-step insertion at the SecY translocon

Nature Structural & Molecular Biology volume 19, pages 975977 (2012) | Download Citation

SecY and Sec61 translocons mediate the orderly insertion of transmembrane segments into the lipid bilayer during membrane-protein biogenesis. Reporting in this issue, Ismail et al. now use a SecM-based molecular force sensor to show that the translocon exerts a pulling force on the nascent chain that is capable of mechanical action at two distinct stages of the insertion process.

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Author information

Affiliations

  1. Soo Jung Kim and William R. Skach are at the Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, USA.

    • Soo Jung Kim
    •  & William R Skach

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to William R Skach.

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DOI

https://doi.org/10.1038/nsmb.2402

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