Recent ensemble and single molecule manipulation studies highlight the mechanical nature of protein unfolding in vivo and, thus, the greater need to understand the response of proteins to mechanical force.
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Matouschek, A., Bustamante, C. Finding a protein's Achilles heel. Nat Struct Mol Biol 10, 674–676 (2003). https://doi.org/10.1038/nsb0903-674
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DOI: https://doi.org/10.1038/nsb0903-674
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