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The bromodomain: a chromatin-targeting module?

Nature Structural Biology volume 6, pages 601–604 (1999)Cite this article

Abstract

It has recently been demonstrated that bromodomains — motifs found in several eukaryotic transcription factors — bind to acetyl-lysine, a modification of histones that is important for transcription. This finding suggests that the regulatory effects of histone acetylation may be exerted by bromodomain-containing proteins.

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Figure 1: Possible models of bromodomain (BD)-mediated partnerships.
Figure 2: Expanded use of bromodomain–ligand interactions involving different covalent histone modifications: variations of the chromatin receptor hypothesis?

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Acknowledgements

We apologize to the many colleagues whose work could not be referenced because of space limitations. We thank M.-H. Kuo for providing Fig. 2. Work in our labs is supported by grants from the National Institutes of Health.

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Authors and Affiliations

  1. the Department of Genetics, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Fred Winston

  2. the Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, 22908, Virginia, USA

    C. David Allis

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  1. Fred Winston
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  2. C. David Allis
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Correspondence to Fred Winston or C. David Allis.

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Winston, F., Allis, C. The bromodomain: a chromatin-targeting module?. Nat Struct Mol Biol 6, 601–604 (1999). https://doi.org/10.1038/10640

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