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The double life of PX domains

Nature Structural Biology volume 8, pages 570–572 (2001)Cite this article

Recent structural and cell biological studies show that the previously uncharacterized PX domain can bind both phospholipids and SH3 domains, suggesting that this module may play a critical role in coordinating membrane localization and protein complex assembly during cell signaling.

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Figure 1: Structure of the p47phox PX domain solved by Hiroaki et al.1.
Figure 2: Possible regulation by multifunctional domains, such as PX domains.

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Authors and Affiliations

  1. the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Ave., San Francisco, 94143-0450, California, USA

    Kenneth E. Prehoda & Wendell A. Lim

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  1. Kenneth E. Prehoda
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  2. Wendell A. Lim
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Correspondence to Wendell A. Lim.

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Prehoda, K., Lim, W. The double life of PX domains. Nat Struct Mol Biol 8, 570–572 (2001). https://doi.org/10.1038/89586

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