mRNA processing: The 3′-end justifies the means

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The U1A protein regulates the activity of poly(A) polymerase by interacting with an RNA element in the 3′ untranslated region of its mRNA. The structure of the trimolecular complex made up of two U1A molecules bound to the target RNA explains the cooperative regulation in this system.

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Figure 1: Schematic of the 3′ untranslated region (3′ UTR) of the U1A pre-mRNA.
Figure 2: Three-dimensional structure of the trimolecular complex of two U1A proteins (shown in purple) and PIE RNA.

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