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Closing in on HIV drug resistance

Nature Structural Biology volume 6, pages 103–106 (1999)Cite this article

Abstract

The structure of a catalytic complex of HIV–1 reverse transcriptase helps rationalize resistance mechanisms for nucleoside analog drugs.

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Figure 1: Schematic diagram of the HIV–1 p66–p51 heterodimer (Ren et al.4).
Figure 2: Schematic diagram of the HIV–1 RT heterodimer in complex with double–stranded DNA (adapted from ref. 2).
Figure 3: Sites of mutations conferring resistance to various nucleoside analog drugs.

References

  1. Huang, H., Chopra, R., Verdine, G.L. & Harrison, S.C. Science 282, 1669–1675 ( 1998).

    Article  CAS  Google Scholar 

  2. Jacobo–Molina et al. Proc. Natl. Acad. Sci. USA 90, 6320– 6324 (1993).

    Article  Google Scholar 

  3. Kohlstaedt et al. Science 256, 1783–1790 ( 1992).

    Article  CAS  Google Scholar 

  4. Ren et al. Nature Struct. Biol. 2, 293–302 (1995).

    Article  CAS  Google Scholar 

  5. Doublie, S. et al. Nature 391, 251–258 (1998).

    Article  CAS  Google Scholar 

  6. Bebenek K. et al. Nature Struct .Biol. 4, 194– 197 (1997).

    Article  CAS  Google Scholar 

  7. Larder, B.A., Purifoy, D.J.M., Powell, K.L. & Darby, G. Nature 327, 716–717 ( 1987).

    Article  CAS  Google Scholar 

  8. Larder, B.A. & Kemp, S.D. Science 246, 1155–1158 (1989).

    Article  CAS  Google Scholar 

  9. Larder, B.A., Darby, G. & Richman, D.D. Science 243, 1731– 1734 (1989).

    Article  CAS  Google Scholar 

  10. Harrigan, P.R. et al. J. Virol. 70, 593– 5934 (1996).

    Google Scholar 

  11. Hooker, D. et al. J. Virol. 70, 8010– 8018 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Kellam, P., Boucher, C.A.B. & Larder, B.A. Proc. Natl. Acad. Sci. U.S.A. 89, 1934–1938 (1992).

    Article  CAS  Google Scholar 

  13. St. Clair, M.H. et al. Science 253, 1557– 1559 (1991).

    Article  CAS  Google Scholar 

  14. Boucher, C.A., et al. Antimicrob. Agents. Chemother. 3, 2231 –2234 (1993).

    Article  Google Scholar 

  15. Gao, Q. et al. Antimicrob. Agents Chemother. 37, 1390– 1392 (1993).

    Article  CAS  Google Scholar 

  16. Schinazi, R.F. et al. Antimicrob. Agents Chemother. 37, 875 –881 (1993).

    Article  CAS  Google Scholar 

  17. Tisdale M., Kemp, S. D., Parry N. R. & Larder B. A. Proc. Natl. Acad. Sci. USA 90, 5653–5656 ( 1993).

    Article  CAS  Google Scholar 

  18. Ollis D.L. et al. Nature 313, 762–766 (1985).

    Article  CAS  Google Scholar 

  19. Ding, J. et al. Nature Struct Biol 2, 407– 15 (1995).

    Article  CAS  Google Scholar 

  20. Esnouf R. et al. Nature Struct Biol. 2, 303–308, (1995).

    Article  CAS  Google Scholar 

  21. Hsiou Y. et al. Structure 4, 853–860 (1996).

    Article  CAS  Google Scholar 

  22. Rodgers, D.W. et al. Proc. Natl. Acad. Sci. USA 92, 1222 –1226 (1995).

    Article  CAS  Google Scholar 

  23. Ren et al. Proc. Natl. Acad. Sci. USA 95, 9518–9523 (1998).

    Article  CAS  Google Scholar 

  24. Boyer, P. L. et al. Proc. Natl. Acad. Sci. USA 91, 4882 –4886 (1994).

    Article  CAS  Google Scholar 

  25. Bloor, S. et al. Antiviral Ther. 3, (suppl 2), Abstract 15 (1998).

    Google Scholar 

  26. de Jong, J. J. et al. Antiviral Ther. 3, (suppl 2), Abstract 18 (1998).

    Google Scholar 

  27. Whitcomb, J.M. et al. Antiviral Ther. 3, (suppl 2), Abstract 17 (1998).

    Google Scholar 

  28. Winters, M. A. et al. J. Clin. Invest. 102, 1769– 1775 (1998).

    Article  CAS  Google Scholar 

  29. Iversen, A. K. N. et al. J. Virol. 70, 1086– 1090 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Shirasaka, T. et al. Proc. Natl. Acad. Sci. USA 92, 2398 –2402 (1995).

    Article  CAS  Google Scholar 

  31. Canard, B., Sarfati, S.R. & Richardson, C.C. J. Biol. Chem. 273, 14596– 14604 (1998).

    Article  CAS  Google Scholar 

  32. Arion, D. et al. Biochemistry 37, 15908– 15917 (1998).

    Article  CAS  Google Scholar 

  33. Esnouf, R.M. J.Mol. Graphics 15, 132–134 (1997).

    Article  CAS  Google Scholar 

  34. Merritt E.A. & Murphy, M.E.P. Acta Crystallogr. D 50, 869–873 (1994).

    Article  CAS  Google Scholar 

  35. Gu, Z. et al. Antimicrob. Agents Chemother. 38, 275– 281 (1994).

    Article  CAS  Google Scholar 

  36. Zhang, D. et al. Antimicrob. Agents Chemother. 38, 282– 287 (1994).

    Article  CAS  Google Scholar 

  37. Fitzgibbon J.E. et al. Antimicrob. Agents Chemother. 36, 153 –157 (1992).

    Article  CAS  Google Scholar 

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Acknowledgements

We wish to thank J.Ren for help with preparing Figs 1 and 2.

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Authors and Affiliations

  1. Virco UK Ltd, 162A, Cambridge Science Park, Milton Road, Cambridge, CB4 4GH, UK

    Brendan A. Larder

  2. Laboratory of Molecular Biophysics, University of Oxford, S. Parks Rd, Oxford, OX1 3QU, UK

    David K. Stammers

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  1. Brendan A. Larder
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  2. David K. Stammers
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Larder, B., Stammers, D. Closing in on HIV drug resistance. Nat Struct Mol Biol 6, 103–106 (1999). https://doi.org/10.1038/5787

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