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Hanging on to the branch

Nature Structural Biology volume 9, pages 5–7 (2002)Cite this article

The mechanism for a critical step in intron recognition has recently been revealed by the structure of the RNA binding domain of splicing factor 1 bound to intronic RNA.

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Figure 1: Comparison of RNA binding by the SF1 KH-QUA2 domain8 and the Nova-2 KH3 domain21.
Figure 2: Stereo view of the SF1 binding pocket for the branch site adenosine8.

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Acknowledgements

I thank P.H. Hutchinson for preparing the figures.

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  1. the Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E. 58th Street, Chicago, 60637, IL, U.S.A.

    Jonathan P. Staley

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Staley, J. Hanging on to the branch. Nat Struct Mol Biol 9, 5–7 (2002). https://doi.org/10.1038/nsb0102-5

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