Molecular lymph node analysis can be used to identify men with prostate cancer at high risk of recurrence and is a better predictor than histopathological analysis alone, according to a new study. Heck and co-workers used both histopathology and molecular analysis (quantification of KLK3 expression) to examine 2,411 of 3,173 lymph nodes from 111 men undergoing radical prostatectomy. They found that molecular lymph node status but not histopathological lymph node status was an independent predictor of biochemical recurrence.