The N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model mimics human muscle-invasive bladder cancer (MIBC) at a molecular and a mutational level, according to a new paper. Fantini and co-workers found that BBN tumours showed overexpression of basal cancer subtype markers and a high mutational burden with frequent mutations in Trp53, Kmt2d, and Kmt2c, similar to human MIBC. They say that their findings provide a strong rationale for using the BBN mouse model in molecular and drug discovery studies.
References
Fantini, D. et al. A carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer. Oncogene https://doi.org/10.1038/s41388-017-0099-6 (2018)
Rights and permissions
About this article
Cite this article
Kelsey, R. BBN mouse model mimics human MIBC. Nat Rev Urol 15, 202 (2018). https://doi.org/10.1038/nrurol.2018.17
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2018.17
