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Male factor infertility

Varicocele repair in the era of assisted reproductive technology

A new publication finds that varicocele repair might improve semen quality enough to enable couples who are awaiting in vitro fertilization or intrauterine insemination to attempt natural conception or less-invasive assisted reproductive techniques. The approach is interesting because it seeks to establish varicocele treatment as one step in a multimodal path to parenthood.

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References

  1. Jensen, C. F. S. et al. Varicocele and male infertility. Nat. Rev. Urol. 14, 523–533 (2017).

    Article  Google Scholar 

  2. Evers, J. L., Collins, J. A. & Vandekerckhove, P. Surgery or embolisation for varicocele in subfertile men. Cochrane Database Syst. Rev. 1, CD000479 (2001).

    Google Scholar 

  3. Kroese, A. C., de Lange, N. M., Collins, J. & Evers, J. L. Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst. Rev. 10, CD000479 (2012).

    PubMed  Google Scholar 

  4. Baazeem, A. et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur. Urol. 60, 796–808 (2011).

    Article  Google Scholar 

  5. Abdel-Meguid, T. A., Al-Sayyad, A., Tayib, A. & Farsi, H. M. Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial. Eur. Urol. 59, 455–461 (2011).

    Article  Google Scholar 

  6. Samplaski, M. K., Lo, K. C., Grober, E. D., Zini, A. & Jarvi, K. A. Varicocelectomy to “upgrade” semen quality to allow couples to use less invasive forms of assisted reproductive technology. Fertil. Steril. 108, 609–612 (2017).

    Article  Google Scholar 

  7. Hurtado de Catalfo, G. E., Ranieri-Casilla, A., Marra, F. A., de Alaniz, M. J. & Marra, C. A. Oxidative stress biomarkers and hormonal profile in human patients undergoing varicocelectomy. Int. J. Androl. 30, 519–530 (2007).

    Article  CAS  Google Scholar 

  8. Wang, Y. J., Zhang, R. Q., Lin, Y. J., Zhang, R. G. & Zhang, W. L. Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis. Reprod. Biomed. Online 25, 307–314 (2012).

    Article  CAS  Google Scholar 

  9. Kirby, E. W., Wiener, L. E., Rajanahally, S., Crowell, K. & Coward, R. M. Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. Fertil. Steril. 106, 1338–1343 (2016).

    Article  Google Scholar 

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Correspondence to Mikkel Fode.

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Fode, M. Varicocele repair in the era of assisted reproductive technology. Nat Rev Urol 14, 705–706 (2017). https://doi.org/10.1038/nrurol.2017.182

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