Intratumour heterogeneity is a critical driver of cancer progression and treatment failure. TRACERx Renal is a prospective study that aims to define the evolutionary trajectories of renal cancer in space and time through multiregion and longitudinal tumour sampling.
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Acknowledgements
S.T. is funded by Cancer Research UK (CRUK; grant reference number C50947/A18176) and the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the Royal Marsden Hospital and Institute of Cancer Research (grant reference number A109). C. S. is funded by CRUK (TRACERx), the Rosetrees Trust, NovoNordisk Foundation (ID 16584), EU FP7 (projects PREDICT and RESPONSIFY, ID: 259303), the Prostate Cancer Foundation, the Breast Cancer Research Foundation, the European Research Council (THESEUS) and NIHR University College London Hospitals BRC.
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S.T. declares no competing interests. C.S. is a consultant for Novartis and Roche, has received speaker's fees from Boehringer Ingelheim, Celgene, Eli Lilly, Epic Biosciences, GlaxoSmithKline, Grail Scientific, Novartis, Pfizer, Roche, and Servier, he is on the advisory board and has stock options of APOGEN Biotechnologies, EPIC Biosciences, and Grail Scientific, and is a founder of and has stock options from Achilles Therapeutics.
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Overview of sampling, tissue processing, and analysis in TRACERx Renal (PDF 472 kb)
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TRACERx Renal consortium. TRACERx Renal: tracking renal cancer evolution through therapy. Nat Rev Urol 14, 575–576 (2017). https://doi.org/10.1038/nrurol.2017.112
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DOI: https://doi.org/10.1038/nrurol.2017.112
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