The identification of patients with very high-risk prostate cancer at an early disease stage remains challenging. Now an analysis of micro-RNA (miRNA) expression patterns in patients with high-risk disease reveals a five-miRNA signature for the identification of such patients. The prognostic value of this panel was evaluated in a total of 28 patients, with a prognostic accuracy of ≥89% for each of the five miRNAs investigated. These data indicate a need for further clinical investigation.
References
Alhasan, A. H. et al. Circulating microRNA signature for the diagnosis of very high-risk prostate cancer. Proc. Natl Acad. Sci. http://dx.doi.org/10.1073/pnas.1611596113 (2016)
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Sidaway, P. Circulating miRNAs indicate high-risk disease. Nat Rev Urol 13, 632 (2016). https://doi.org/10.1038/nrurol.2016.191
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DOI: https://doi.org/10.1038/nrurol.2016.191
