Results from the extension of the RELAX study have shown that repeat onabotulinumtoxin A treatment in women with refractory idiopathic detrusor overactivity has consistent efficacy and duration of action. Up to three injections of treatment or placebo were offered to patients over a 5-year period and no statistically significant differences for symptom outcomes or time to symptom return were observed between injections.
References
Owen, R. K. et al. Comparison of the effectiveness of repeated injections of onabotulinum toxin A for refractory idiopathic detrusor overactivity: analysis of an open label extension of a randomized trial (the RELAX study). Neurourol. Urodyn. http://dx.doi.org/10.1002/nau.23095 (2016)
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Stone, L. Results of the RELAX study extension. Nat Rev Urol 13, 566 (2016). https://doi.org/10.1038/nrurol.2016.179
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DOI: https://doi.org/10.1038/nrurol.2016.179