Lower urinary tract symptoms (LUTS) such as urgency incontinence are a common problem in patients with multiple sclerosis (MS), and can seriously affect the quality of life of these patients. Now, data from a prospective study shows that, in patients with MS who have lesions of the pontine micturition centre (PMC), a greater lesion diameter is positively correlated with weak urinary stream, and urgency incontinence as confirmed using symptom-specific questionnaires. These data suggest that a patient's individual CNS lesion characteristics could be used to predict LUT symptoms.