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PSMA PET–CT in initial prostate cancer staging

The speed with which PSMA PET–CT has been adopted for prostate cancer imaging is unprecedented. This technique's clinical value in recurrent disease is uncontested, but its role in initial staging is unclear. Two studies now provide important data on the value of PSMA PET–CT at this management stage.

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Figure 1: Prostate-specific membrane antigen (PSMA) PET–CT imaging.

References

  1. van Leeuwen, P. J. et al. Prospective evaluation of 68Gallium-PSMA positron emission tomography/computerized tomography for preoperative lymph node staging in prostate cancer. BJU Int. http://dx.doi.org/10.1111/bju.13540 (2016).

  2. Rhee, H. et al. PSMA PET may improve the diagnostic accuracy of mpMRI in localised prostate cancer as confirmed by whole-mount histopathology. J. Urol. http://dx.doi.org/10.1016/j.juro.2016.02.3000 (2016).

  3. Budäus, L. et al. Initial experience of 68Ga-PSMA PET/CT imaging in high-risk prostate cancer patients prior to radical prostatectomy. Eur. Urol. 69, 393–396 (2016).

    Article  Google Scholar 

  4. Maurer, T. et al. Diagnostic efficacy of 68Gallium-PSMA positron emission tomography compared to conventional imaging in lymph node staging of 130 consecutive patients with intermediate to high risk prostate cancer. J. Urol. 195, 1436–1443 (2016).

    Article  Google Scholar 

  5. Giesel, F. L. et al. PSMA PET/CT with Glu-urea-Lys-(Ahx)-[68Ga(HBED-CC)] versus 3D CT volumetric lymph node assessment in recurrent prostate cancer. Eur. J. Nucl. Med. Mol. Imaging 42, 1794–1800 (2015).

    Article  CAS  Google Scholar 

  6. Rahbar, K. et al. Correlation of intraprostatic tumor extent with 68Ga–PSMA distribution in patients with prostate cancer. J. Nucl. Med. 57, 563–567 (2016).

    Article  CAS  Google Scholar 

  7. Zamboglou, C. et al. MRI versus 68Ga-PSMA PET/CT for gross tumour volume delineation in radiation treatment planning of primary prostate cancer. Eur. J. Nucl. Med. Mol. Imaging 43, 889–897 (2016).

    Article  CAS  Google Scholar 

  8. Eiber, M. et al. Simultaneous 68Ga-PSMA HBED-CC PET/MRI improves the localization of primary prostate cancer. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2015.12.053 (2016).

  9. Pinaquy, J. B. et al. Comparative effectiveness of [18F]-fluorocholine PET-CT and pelvic MRI with diffusion-weighted imaging for staging in patients with high-risk prostate cancer. Prostate 75, 323–331 (2015).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Frederik A. Verburg.

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F.A.V. is a consultant to Bayer Healthcare and Genzyme. A.P. declares no competing interests.

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Verburg, F., Pfestroff, A. PSMA PET–CT in initial prostate cancer staging. Nat Rev Urol 13, 498–499 (2016). https://doi.org/10.1038/nrurol.2016.136

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