Testosterone therapy for men with prostate cancer is a controversial topic. A recent study retrospectively reviewed a single-centre experience in treating hypogonadal men with prostate cancer with exogenous testosterone therapy and found it to be safe.
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References
Huggins, C. & Hodges, C. V. The effect of castration, of estrogen and of androgen injection on serum phosphatase on metastatic carcinoma of the prostate. Cancer Res. 1, 293–297 (1941).
Ory, J. et al. Testosterone therapy in patients with treated and untreated prostate cancer: impact on oncologic outcomes. J. Urol. http://dx.doi.org/10.1016/j.juro.2016.04.069 (2016).
Zumsteg, Z. S. et al. The natural history and predictors of outcome following biochemical relapse in the dose escalation era for prostate cancer patients undergoing definitive external beam radiotherapy. Eur. Urol. 67, 1009–1016 (2015).
Kaplan, A. L. et al. Testosterone therapy in men with prostate cancer. Eur. Urol. 69, 894–903 (2016).
Dohle, G. R. et al. Guidelines on male hypogonadism. European Association of Urology http://uroweb.org/wp-content/uploads/EAU-Guidelines-Male-Hypogonadism-2015.pdf (2015).
Rhoden, E. L. & Morgentaler, A. Risks of testosterone-replacement therapy and recommendations for monitoring. N. Engl. J. Med. 350, 482–492 (2004).
Morgentaler, A. & Traish, A. M. Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. Eur. Urol. 55, 310–321 (2009).
Crawford, E. D. et al. Effects of testosterone level on lower urinary tract symptoms. Am. J. Mens Health http://dx.doi.org/10.1177/1557988315590655 (2015).
Kacker, R. et al. Can testosterone therapy be offered to men on AS for prostate cancer? Preliminary results. Asian J. Androl. 17, 1–5 (2015).
San Francisco, I. F., Rojas, P. A., DeWolf, W. C. & Morgentaler, A. Low free testosterone levels predict disease reclassification in men with prostate cancer undergoing active surveillance. BJU Int. 114, 229–235 (2014).
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Catarinicchia, S., Crawford, E. Testosterone therapy for hypogonadal men with prostate cancer. Nat Rev Urol 13, 497–498 (2016). https://doi.org/10.1038/nrurol.2016.118
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DOI: https://doi.org/10.1038/nrurol.2016.118