Treatment options in patients with unresectable advanced penile cancer are limited owing to a lack of large, randomized prospective studies. A recent multicentre trial evaluated the use of gemcitabine plus cisplatin in such patients but the results were disappointing. What is the future of systemic therapy for advanced penile cancer?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hakenberg, O. W. et al. EAU guidelines on penile cancer: 2014 update. Eur. Urol. 67, 142–150 (2015).
Kirrander, P. et al. The Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival. BJU Int. http://dx.doi.org/10.1111/bju.12993.
Leijte J.A., Kerst, J. M., Bais, E., Antonini, N. & Horenblas, S. Neoadjuvant chemotherapy in advanced penile carcinoma. Eur. Urol. 52, 488–494 (2007).
Houédé, N. et al. Intermediate analysis of a phase II trial assessing gemcitabine and cisplatin in locoregional or metastatic penile squamous cell sarcinoma. BJU Int. http://dx.doi.org/10.1111/bju.13054.
Haas, G.P. et al. Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J. Urol. 161, 1823–1825 (1999).
Di Lorenzo, G. et al. Cisplatin and 5-fluorouracil in inoperable, stage IV squamous cell carcinoma of the penis. BJU Int. 110, E661–E666 (2012).
Theodore, C. et al. A phase II multicentre study of irinotecan (CPT 11) in combination with cisplatin (CDDP) in metastatic or locally advanced penile carcinoma (EORTC PROTOCOL 30992). Ann. Oncol. 19, 1304–1307 (2008).
Pagliaro, L. C. et al. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. Clin. Oncol. 28, 3851–3857 (2010).
Nicholson, S. et al. Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001). Br. J. Cancer 109, 2554–2559 (2013).
Carthon, B. C., Ng, C. S., Pettaway, C. A. & Pagliaro, L. C. Epidermal growth factor receptor-targeted therapy in locally advanced or metastatic squamous cell carcinoma of the penis. BJU Int. 113, 871–877 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Sharma, P., Spiess, P. Advanced penile cancer continues to elude systemic therapy. Nat Rev Urol 12, 185–186 (2015). https://doi.org/10.1038/nrurol.2015.30
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2015.30
