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Prostate cancer

Alcohol, cancer and 5α-reductase inhibitors—is there a link?

Nature Reviews Urology volume 11, pages 253–254 (2014)Cite this article

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Two major trials have been performed to determine the effect of 5α-reductase inhibitors on subsequent diagnoses of prostate cancer. Both trials showed that high alcohol intake significantly increased prostate cancer risk among men allocated to the treatment arms. The recommendation that patients eliminate alcohol when taking 5α-reductase inhibitors seems appropriate.

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References

  1. Fowke, J. H., Howard, L., Andriole, G. L. & Freedland, S. J. Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2014.01.037.

  2. Andriole, G. L. et al. Effect of dutasteride on the risk of prostate cancer. N. Engl. J. Med. 362, 1192–1202 (2010).

    Article  CAS  Google Scholar 

  3. Jin, M. et al. Alcohol drinking and all cancer mortality: a meta-analysis. Ann. Oncol. 24, 807–816 (2013).

    Article  CAS  Google Scholar 

  4. Thompson, I. M. et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 349, 213–222 (2003).

    Article  Google Scholar 

  5. Gong, Z. et al. Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer 115, 3661–3669 (2009).

    Article  CAS  Google Scholar 

  6. Mukamal, K. J. Overview of the risks and benefits of alcohol consumption. UpToDate [online], (2014).

    Google Scholar 

  7. Freedland, S. J. et al. Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study. Prostate Cancer Prostatic Dis. 16, 254–259 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 1112, Philadelphia, 19107, PA, USA

    Leonard G. Gomella

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  1. Leonard G. Gomella
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Correspondence to Leonard G. Gomella.

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Competing interests

The author declares that he is a past steering committee member on the REDUCE trial.

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Gomella, L. Alcohol, cancer and 5α-reductase inhibitors—is there a link?. Nat Rev Urol 11, 253–254 (2014). https://doi.org/10.1038/nrurol.2014.90

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