Researchers have successfully performed whole-exome sequencing of a bone metastasis from a man with metastatic castration-resistant prostate cancer, identifying somatic genomic alterations that dysregulate the phosphoinostide 3-kinase pathway and a germline variant in the BRCA2 gene, and demonstrating the feasibility of diagnostic bone metastases profiling and analysis.
References
Van Allen, E. M. et al. Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy. Prostate Cancer Prostatic Dis. 10.1038/pcan.2013.37
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Whole-exome sequencing of bone metastasis biopsy. Nat Rev Urol 11, 67 (2014). https://doi.org/10.1038/nrurol.2014.5
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DOI: https://doi.org/10.1038/nrurol.2014.5
