In a recent study of 183,842 men with locoregional prostate cancer, 48.4% of whom received a gonadotropin-releasing hormone (GnRH) agonist and 2.2% of whom underwent bilateral orchiectomy, treatment with a GnRH agonist was associated with a significantly higher incidence of biliary disease compared with no treatment (15.7 cases vs 13.4 cases per 1,000 person-years). Androgen deprivation by orchiectomy, on the other hand, had no effect on risk of biliary disease.
References
Saylor, P. J. et al. Androgen-deprivation therapy and risk for biliary disease in men with prostate cancer. Eur. Urol. 10.1016/j.eururo.2013.02.003
Rights and permissions
About this article
Cite this article
GnRH treatment could increase the risk of biliary disease. Nat Rev Urol 11, 129 (2014). https://doi.org/10.1038/nrurol.2014.40
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2014.40
