Researchers have identified new gene targets that might be useful for the development of novel therapies against urinary tract infection (UTI) caused by Escherichia coli. Subashchandrabose and co-workers used total RNA-sequencing and comparative transcriptional analysis to identify novel genes that promote survival of the bacterium within the human urinary tract during naturally occurring, uncomplicated UTI in women.
References
Subashchandrabose, S. et al. Host-specific induction of Escherichia coli fitness genes during human urinary tract infection. Proc. Natl Acad. Sci. USA 10.1073/pnas.1415959112
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E. coli genes that promote survival during human UTI found. Nat Rev Urol 12, 64 (2015). https://doi.org/10.1038/nrurol.2014.366
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DOI: https://doi.org/10.1038/nrurol.2014.366
