The contemporary plea for a more liberal pathological definition of insignificant prostate cancer was recently challenged by Schiffmann and colleagues, who advocate a return to the original, stringent 0.5 ml tumour volume threshold. This cut-off point would render fewer men eligible for active surveillance programmes.
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The authors declare no competing financial interests.
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van der Kwast, T., Roobol, M. Is prostatectomy for Gleason score 6 a treatment failure?. Nat Rev Urol 12, 10–11 (2015). https://doi.org/10.1038/nrurol.2014.335
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