For large prostates, plasmakinetic enucleation is noninferior to open prostatectomy, according to new research from China. 123 men with prostates weighing >100 g finished 6-year follow-up assessment after randomization to receive either plasmakinetic enucleation or open prostatectomy. On intention-to-treat analysis, both groups demonstrated equivalent maximum urinary flow rate, International Prostate Symptom Score, quality of life and postvoid residual urine at 72 months after the procedure. Plasmakinetic enuclation was associated with fewer short-term complications.