A prospective study of 49,898 male health professionals, followed from 1986 to 2010, has demonstrated an association between high dietary lycopene intake and reduced risk of prostate cancer, particularly lethal prostate cancer. Notably, the association was stronger in the subset of men who underwent PSA screening. In addition, biomarker analysis revealed lower levels of angiogenesis in prostate tumours from men who reported higher lycopene intake.