A large population-based survey has evaluated the bother associated with different lower urinary tract symptoms to identify the most bothersome. Analysis of 3,727 patients' responses to a questionnaire regarding 12 different symptoms revealed that urinary urgency, stress urinary incontinence and nocturia were the most common symptoms associated with bother at the population level, whereas individuals were more likely to rate urgency incontinence as bothersome than other lower urinary tract symptoms.