In a pilot open-label study, 18 patients with chronic scrotal pain who had failed other treatment but had temporary symptom relief after standard cord block received 100 U of onabotulinumtoxinA to asses long-term pain relief. Decreases in pain measured by 10-point analogue scale pain score, scrotal tenderness by physical examination and reduction in Chronic Epididymitis Symptom Index score were reported for up to 3 months after treatment. After 6 months, most men returned to baseline levels of pain and tenderness.