A study in 116 patients with positive surgical margins after prostatectomy for localized disease examined whether early postoperative PSA levels can be used to stratify the risk of disease progression. 47% of patients had biochemical recurrence during 31.4 months median follow-up. PSA levels 30 days after prostatectomy had predictive accuracy; concentrations >0.073 ng/ml significantly increased the risk of biochemical recurrence (HR = 4.35). Predictive accuracy was further significantly increased for PSA measurements on day 60, but not for later measurements.
References
Vesely, S. et al. The use of early postoperative prostate-specific antigen to stratify risk in patients with positive surgical margins after radical prostatectomy. BMC Urol. 14, 79 (2014)
Rights and permissions
About this article
Cite this article
Early PSA measurement can predict recurrence. Nat Rev Urol 11, 660 (2014). https://doi.org/10.1038/nrurol.2014.297
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2014.297