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Decade in review—sexual dysfunction

Post-RP erectile dysfunction—therapies for the next decade

Erectile dysfunction remains a frequent sequela of radical prostatectomy, owing to injury to the cavernous nerves that innervate the penile erectile tissue. Over the last decade, many strategies have been proposed to minimize the duration of denervation and prevent irreversible structural changes from occurring in the corpora cavernosa.

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References

  1. Boorjian, S. A. S. et al. A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes. Eur. Urol. 61, 664–675 (2012).

    Article  Google Scholar 

  2. Kim, E. D. et al. Interposition of sural nerve restores function of cavernous nerves resected during radical prostatectomy. J. Urol. 161, 188–192 (1999).

    Article  CAS  Google Scholar 

  3. Namiki, S. et al. Impact of unilateral sural nerve graft on recovery of potency and continence following radical prostatectomy: 3-year longitudinal study. J. Urol. 178, 212–216 (2007).

    Article  Google Scholar 

  4. Davis, J. W. et al. Randomized Phase II trial evaluation of erectile function after attempted unilateral cavernous nerve-sparing retropubic radical prostatectomy with versus without unilateral sural nerve grafting for clinically localized prostate cancer. Eur. Urol. 55, 1135–1144 (2009).

    Article  Google Scholar 

  5. Padma-Nathan, H. et al. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Int. J. Impot. Res. 20, 479–486 (2008).

    Article  CAS  Google Scholar 

  6. Montorsi, F. et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur. Urol. 54, 924–931 (2008).

    Article  CAS  Google Scholar 

  7. Montorsi, F. et al. Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur. Urol. 65, 587–596 (2014).

    Article  CAS  Google Scholar 

  8. Sezen, S. F., Lagoda, G. & Burnett, A. L. Role of immunophilins in recovery of erectile function after cavernous nerve injury. J. Sex. Med. 6, 340–346 (2009).

    Article  CAS  Google Scholar 

  9. Bella, A. J. et al. Brain-derived neurotrophic factor (BDNF) acts primarily via the jak/stat pathway to promote neurite growth in the major pelvic ganglion of the rat: part I. J. Sex. Med. 3, 815–820 (2006).

    Article  CAS  Google Scholar 

  10. Fandel, T. M. et al. recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur. Urol. 61, 201–210 (2011).

    Article  Google Scholar 

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Correspondence to Maarten Albersen.

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Weyne, E., Albersen, M. Post-RP erectile dysfunction—therapies for the next decade. Nat Rev Urol 11, 616–618 (2014). https://doi.org/10.1038/nrurol.2014.274

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