In response to the demand for reconstructive options that preserve quality of life after cystectomy, 2013 saw considerable advances in biocompatible meshes and stem cell preparations that might recapitulate the urinary bladder. With increasing strength and functionality of these substitutes, what challenges remain?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hautmann, R. E. et al. ICUD–EAU International Consultation on Bladder Cancer 2012: urinary diversion. Eur. Urol. 63, 67–80 (2013).
Ravi, P. et al. Benefit in regionalisation of care for patients treated with radical cystectomy: a nationwide inpatient sample analysis. BJU Int. http://dx.doi.org/10.1111/bju.12288.
Sun, W. et al. Improving the cell distribution in collagen-coated poly-caprolactone knittings. Tissue Eng. Part C Methods 18, 731–739 (2012).
Hoogenkamp, H. et al. Seamless vascularized large-diameter tubular collagen scaffolds reinforced with polymer knittings for esophageal regenerative medicine. Tissue Eng. Part C Methods http://dx.doi.org/10.1089/ten.TEC.2013.0485.
Tu, D. D. et al. Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty. Biomaterials 34, 8681–8689 (2013).
Vaegler, M., Amend, B., Aicher, W., Stenzl, A. & Sievert, K. D. Stem cell therapy and tissue engineering in regenerative urology [German]. Urologe A 52, 1671–1678 (2013).
Sharma, A. K. et al. Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration. Proc. Natl Acad. Sci. USA 110, 4003–4008 (2013).
Hart, M. L. et al. Cell-based therapy for the deficient urinary sphincter. Curr. Urol. Rep. 14, 476–487 (2013).
van Koeveringe, G., Rademakers, K. & Stenzl, A. Latissimus dorsi detrusor myoplasty to restore voiding in patients with an acontractile bladder—fact or fiction? Curr. Urol. Rep. 14, 426–434 (2013).
Vrana, N. E. et al. Engineering functional epithelium for regenerative medicine and in vitro organ models: a review. Tissue Eng. Part B Rev. 19, 529–543 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Stenzl, A. Recapitulating the urinary bladder—where are we heading?. Nat Rev Urol 11, 70–71 (2014). https://doi.org/10.1038/nrurol.2013.315
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2013.315
