Circulating tumour cells might not only seed distant organs but also reseed the original cancer site, leading to accelerated tumour growth and decreased survival. A recent study suggests that radical prostatectomy might reduce the risk of reseeding and subsequent disease progression in patients with metastatic prostate cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Akakura, K. et al. A randomized trial comparing radical prostatectomy plus endocrine therapy versus external beam radiotherapy plus endocrine therapy for locally advanced prostate cancer: results at median follow-up of 102 months. Jpn J. Clin. Oncol. 36, 789–793 (2006).
Paulson, D. F., Lin, G. H., Hinshaw, W. & Stephani, S. Radical surgery versus radiotherapy for adenocarcinoma of the prostate. J. Urol. 128, 502–504 (1982).
Penson, D. F. An update on randomized clinical trials in localized and locoregional prostate cancer. Urol. Oncol. 23, 280–288 (2005).
Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2013. CA Cancer J. Clin. 63, 11–30 (2013).
Kim, M. Y. et al. Tumor self-seeding by circulating cancer cells. Cell 139, 1315–1326 (2009).
Shao, Y. H. et al. Cancer-specific survival after metastasis following primary radical prostatectomy compared with radiation therapy in prostate cancer patients: results of a population-based, propensity score–matched analysis. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2013.05.023.
Hoffman, R. M., Stone, S. N., Hunt, W. C., Key, C. R. & Gilliland, F. D. Effects of misattribution in assigning cause of death on prostate cancer mortality rates. Ann. Epidemiol. 13, 450–454 (2003).
Warlick, C., Trock, B. J., Landis, P., Epstein, J. I. & Carter, H. B. Delayed versus immediate surgical intervention and prostate cancer outcome. J. Natl Cancer Inst. 98, 355–357 (2006).
Comen, E., Norton, L. & Massagué, J. Clinical implications of cancer self-seeding. Nat. Rev. Clin. Oncol. 8, 369–377 (2011).
Aguirre-Ghiso, J. A. On the theory of tumor self-seeding: implications for metastasis progression in humans. Breast Cancer Res. 12, 304 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Moghanaki, D., Anscher, M. Should men with metastases undergo radical prostatectomy?. Nat Rev Urol 10, 501–502 (2013). https://doi.org/10.1038/nrurol.2013.154
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2013.154