Assessment of the clinical validity of the 2004 WHO grading system for bladder cancer staged pTa revealed three important aspects: the presence of substantial interobserver variability; that tumor grade is analogous to stage; and that the system has prognostic value (as low-grade tumors progress, but do so sporadically).
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Burger, M., Goebell, P. Validity of the 2004 system for grading Ta bladder cancer. Nat Rev Urol 9, 126–127 (2012). https://doi.org/10.1038/nrurol.2012.8
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DOI: https://doi.org/10.1038/nrurol.2012.8
