Treatment of diabetic mice with cyanidin-3-O-β-D-glucopyranoside extracted from mulberry fruit improves erectile function compared with diabetic mice that did not receive the treatment. The corporal tissues of the treated mice showed increased expression of nitric oxide synthase (NOS) and NOS protein and lower levels of apotosis. Adding to the evidence that the mulberry extract minimizes oxidative stress, treatment recovered the level of 8-hydroxy-2-deoxyguanosine in the diabetic mice to that of healthy mice.
ORIGINAL RESEARCH PAPER
Ha, U. et al. Cyanidin-3-O-β-D-glucopyranoside concentrated materials from mulberry fruit have a potency to protect erectile function by minimizing oxidative stress in a rat model of diabetic erectile dysfunction. Urol. Int. doi:10.1159/000336136
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Mulberry extract improves erectile function in diabetic mice. Nat Rev Urol 9, 236 (2012). https://doi.org/10.1038/nrurol.2012.64
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DOI: https://doi.org/10.1038/nrurol.2012.64