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Prostate cancer

Making the switch from LHRH antagonist to LHRH agonist

One very important issue faced by clinicians managing patients with prostate cancer is whether after initiating a man on a pure luteinizing-hormone-releasing hormone (LHRH) antagonist, he should then be switched to a longer-acting depot LHRH agonist. New evidence suggests that this therapeutic approach is both safe and effective.

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References

  1. Garnick, M. B. & Mottet, N. New treatment paradigm for prostate cancer: abarelix initiation therapy for immediate testosterone suppression followed by a luteinizing hormone-releasing hormone agonist. BJU Int. http://dx.http://dx.doi.org/10.1111/j.1464-410X.2011.10708.x.

  2. McLeod, D. et al. A phase 3, multicenter, open-label, randomized study of abarelix versus leuprolide acetate in men with prostate cancer. Urology 58, 756–761 (2001).

    Article  CAS  Google Scholar 

  3. Mongiat-Artus, P. & Teillac, P. Abarelix: the first gonadotrophin-releasing hormone antagonist for the treatment of prostate cancer. Expert Opin. Pharmacother. 5, 2171–2179 (2004).

    Article  CAS  Google Scholar 

  4. Klotz, L. et al. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancer. BJU Int. 102, 1531–1538 (2008).

    Article  CAS  Google Scholar 

  5. Crawford, E. D. et al. A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. J. Urol. 186, 889–897 (2011).

    Article  CAS  Google Scholar 

  6. Tombal, B. et al. Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics. Eur. Urol. 57, 836–842 (2010).

    Article  CAS  Google Scholar 

  7. Schröder, F. H. et al. Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study. BJU Int. 106, 182–187 (2010).

    Article  Google Scholar 

  8. Dreicer, R., Bajorin, D. F., McLeod, D. G., Petrylak, D. P. & Moul, J. W. New data, new paradigms for treating prostate cancer patients--VI: novel hormonal therapy approaches. Urology 78 (5 Suppl.), S494–S498 (2011).

    Article  Google Scholar 

  9. Moul, J. W. Twenty-five year evolution of medical hormonal therapy for prostate cancer. BJU Int. 103, 145–146 (2009).

    Article  Google Scholar 

  10. Ryan, C. J. & Tindall, D. J. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J. Clin. Oncol. 29, 3651–3658 (2011).

    Article  CAS  Google Scholar 

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The author has been a consultant for and received speakers bureau (honoraria) from Ferring.

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Moul, J. Making the switch from LHRH antagonist to LHRH agonist. Nat Rev Urol 9, 125–126 (2012). https://doi.org/10.1038/nrurol.2012.5

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